Oxygen consumption, glycolysis, and sodium reabsorption in the hypothyroid rat kidney.

HOLMES, EDWARD W., JR-, AND VINCENT A. DISCALA. Oxygen consumption, glycolysis, and sodium reabsorption in the hypothyroid rat kidney. Am. J. Physiol. 221(3) : 839-843. 1971.-Rates of oxygen consumption (Qog) and anaerobic glycolysis (Qco~) were determined in renal tissue slices from control and hypothyroid rats. Qcoz was 19 c/0 lower (I’ < 0.05) in tissue from the inner medulla of hypothyroid than control rats. Qoz of cortical slices prepared from nondiuretic animals was 24% lower (a < 0.001) in hypothyroid than control rats. After control and hypothyroid animals had each been infused with 2,500 ,uEq of sodium per 100 g body wt, tubular sodium reabsorption was 2770 lower (P < 0.01) and Qo2 of cortical slices was 30% lower (P < 0.001) in hypothyroid than control rats. The present demonstration of a reduced rate of sodium reabsorption and reduced rate of aerobic and glycolytic metabolism in the hypothroid rat kidney may provide an explanation for the exaggerated natriuresis previously documented in these animals.